Aethina tumida (Coleoptera: Nitidulidae - Small Pump Inlet Seal Hive Beetle - SHB), is a parasite of honey bee colonies that causes the notifiable disease called aethinosis.In 2014, SHB was detected in Southern Italy, where it is still present (Calabria region).As part of surveillance activities, official diagnosis of the disease is performed by ve
Over the last quarter century, more than 532 genes have been put forward as regulatory targets of retinoic acid.In some cases this control is direct, driven by a liganded heterodimer of retinoid receptors bound to a DNA response element; in others, it is indirect, reflecting the actions of intermediate transcription factors, non-classical associati
Summary: BRCA1 promotes homologous recombination (HR) by activating DNA-end resection.By contrast, 53BP1 forms a barrier that inhibits DNA-end resection.Here, we show that BRCA1 promotes DNA-end resection by relieving the 53BP1-dependent barrier.We show that 53BP1 is phosphorylated by ATM in S/G2 phase, promoting RIF1 recruitment, which inhibits re
Objectives Factors associated with multimorbidity, polypharmacy and Medication Regimen Complexity Index (MRCI) may vary across countries.However, such data are lacking in the present study setting.This study aimed to identify factors associated with multimorbidity, polypharmacy and MRCI among adults living with hypertension in public hospitals of S